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At Torrance Memorial Physician Network - Cancer Care, we are committed to the advancement of effective new cancer therapy.

Active Trials TRIO-US

The following clinical trials are available at Torrance Memorial Physician Network - Cancer Care in coordination with the TRIO-US/Clinical Trials Network. This is a unique opportunity for patients in the South Bay to receive advanced research treatments previously restricted to university cancer centers. TRIO-US/Clinical Trials Network affiliated program places Torrance Memorial Physician Network patients into the promising new era of cancer treatment research. All patients enrolled in these trials are treated at our infusion center in Redondo Beach.

The following studies are subject to change by TRIO-US/Clinical Trials Network and the participating pharmaceutical companies and may not be continually or currently open. Enrollment and participation in these studies is voluntary and patients can choose to withdraw at any time and for any reason. All experimental study drugs are provided at no charge.

Each study has precise entry criteria for enrollment because the researchers are attempting to answer a specific treatment question, within a specific clinical parameter, so not all interested patients will be eligible to participate. It is notable that most of the studies involve drugs that are pathway-specific or targeted, which has been a major trend in cancer research over the past decade as the molecular secrets of cancer growth are revealed.

Disease Title Summary Status Investigator
Breast Cancer RAVEL RB-AG-PLT-01 "EMBRACE" Evaluation of Novel Blood-Based Biomarkers for Detection of Breast Cancer (EMBRACE) Open/Active Swati Sikaria, MD
GI- COLORECTAL CANCER (CRC) NATERA "BESPOKE" 20-041-NCP BESPOKE Study of ctDNA Guided Therapy in Colorectal Cancer Open/Active Syed Jilani, MD
SOLID TUMOR LAM "ELITE" 001-2018 Collection of Blood from Healthy Patients, Patients with Benign Disease and Patients with Cancer Open/Active David Chan, MD

Active Trials - UCLA Trials

The following clinical trials are available at Torrance Memorial Physician Network Cancer Care and are in coordination with the TRIO-US / Clinical Trials Network.

Disease Title Summary Status Investigator
BREAST TRIO 033 ‐ Novartis CLEE011O12301C "NATALEE" Phase III, multicenter, randomized, open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as an adjuvant treatment in patients with hormone receptor-positive, HER2-negative, early breast cancer (New Adjuvant TriAl with Ribociclib [LEE011]:NATALEE) Open/Active David Chan, MD
BREAST NSABP B-59 / GBG 96-GeparDouze TNBC A Randomized, Double-Blind, Phase III Clinical Trial of Neoadjuvant Chemotherapy with Atezolizumab or Placebo in Patients with Triple-Negative Breast Cancer Followed by Adjuvant Continuation of Atezolizumab or Placebo. Open/Active David Chan, MD
BREAST Seattle Genetics SGNTUC-016 "HER2 CLIMB-02" Randomized, double-blind, phase 3 study of tucatinib or placebo in combination with adotrastuzumab emtansine (T-DM1) for subjects with unresectable locally-advanced or metastatic HER2+ breast cancer. Open/Active David Chan, MD
BREAST TRIO-038 - Roche WO42133 A RANDOMIZED, MULTICENTER, OPEN-LABEL, TWO-ARM, PHASE II, NEOADJUVANT STUDY EVALUATING THE EFFICACY, SAFETY, AND PHARMACOKINETICS OF GDC-9545 PLUS PALBOCICLIB COMPARED WITH POSTMENOPAUSAL WOMEN. ANASTROZOLE PLUS PALBOCICLIB FOR Open/Active David Chan, MD
BREAST TRIO-US B-12 (TALENT) A Phase II, Multicenter, Open-Label Trial to Evaluate the Safety and Efficacy of trastuzumab deruxtecan (DS-8201a) with or without anastrozole for HER2 Low Hormone Receptor Positive (HR+) Breast Cancer in the Neoadjuvant Setting Open/Active David Chan, MD
PANCREATIC Ipsen "NAPOLI-3" An open-label, randomised, multicentre, phase III study of irinotecan liposome injection, oxaliplatin, 5-fluorouracil / leucovorin versus nab-paclitaxel plus gemcitabine in subjects who have not previously received chemotherapy for metastatic adenocarcinoma of the pancreas. Open/Active Hugo Hool, MD
LUNG - NON SMALL CELL LUNG CANCER Mirati 516-005 "SAPPHIRE" A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy. Open/Active Thomas Lowe, MD
CHRONIC LYMPHOCYTIC LEUKEMIA Acerta ACE-CL-311 (D8221C00001) CLL A Randomized, Multicenter, Open-Label, Phase 3 Study to Compare the Efficacy and Safety of Acalabrutinib (ACP-196) in Combination with Venetoclax with and without Obinutuzumab Compared to Investigator's Choice of Chemoimmunotherapy in Subjects with Previously Untreated Chronic Lymphocytic Leukemia Without del(17p) or TP53 Mutation. Open/Active Swati Sikaria, MD

Cedars-Sinai Trials

Disease Title Summary Status Investigator
BRAIN METASTASES NCI ALLIANCE A071701 GENOMICALLY-GUIDED TREATMENT TRIAL IN BRAIN METASTASES Open/Active Andrew Horodner, MD & Jeremy Rudnick, MD
BREAST-DCIS AFT-25 "COMET" COMPARISON OF OPERATIVE TO MONITORING AND ENDOCRINE THERAPY (COMET) TRIAL FOR LOW RISK DCIS: A PHASE III PROSPECTIVE RANDOMIZED TRIAL, https://dcisoptions.org/ Open/Active Swati Sikaria, MD
BREAST NCI ALLIANCE A011401 "BWEL" RANDOMIZED PHASE III TRIAL EVALUATING THE ROLE OF WEIGHT LOSS IN ADJUVANT TREATMENT OF OVERWEIGHT AND OBESE WOMEN WITH EARLY BREAST CANCER Open/Active Swati Sikaria, MD & Arash Asher, MD
BREAST NCI ALLIANCE A221505 "RT CHARM" RT CHARM: PHASE III RANDOMIZED TRIAL OF HYPOFRACTIONATED POST MASTECTOMY RADIATION WITH BREAST RECONSTRUCTION Open/Active Swati Sikaria, MD & Michelle Burnison, MD
GI- COLORECTAL CANCER (CRC) NCI SWOG LUNGMAP LUNGMAP: A MASTER PROTOCOL TO EVALUATE BIOMARKER-DRIVEN THERAPIES AND IMMUNOTHERAPIES IN PREVIOUSLY-TREATED NON-SMALL CELL LUNG CANCER (Lung-MAP Screening Study) Open/Active Andrew Horodner, MD & Karen Reckamp, MD
SOLID TUMOR "TAPUR" BY ASCO The Targeted Agent and Profiling Utilization Registry (TAPUR) Study, WWW.TAPUR.COM Open/Active Swati Sikaria, MD & Omid Hamid, MD